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ClinVar has an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice web page are a relatively common reason behind aberrant splicing (PMID: 17576681, 9536098). Algorithms made to predict the influence of sequence modifications on RNA splicing recommend that this variant might build or strengthen a splice web site. In summary, the obtainable evidence is at the moment insufficient to ascertain the part of this variant in condition. As a result, it has been categorised to be a Variant of Unsure Significance. (much less)

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Stars symbolize the evaluation position, or the level of review supporting the submitted (SCV) report. This worth is calculated by NCBI according to details through the submitter.

This benefit is calculated by NCBI based on information from submitters. Go through our principles for calculating the evaluation position. The number of submissions which contribute to this overview standing is revealed in parentheses.

There isn't any practical evidence in ClinVar for this variation. If you have created purposeful details for this variation, be sure to take into consideration publishing that data to ClinVar.

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These citations are recognized by LitVar using the rs amount, so they may consist of citations for multiple variant at this locale. You should critique the LitVar benefits cautiously to your variant of interest. History final up to date May well 19, 2024 

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The quantity of variants in ClinVar that are contained inside of this gene, by using a connection to view the list of variants.

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The worldwide minor allele frequency calculated with the one thousand Genomes Challenge. The minor allele at this spot is indicated in parentheses and will be unique from the allele represented by this VCV document.

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